Claudio Vinegoni, Ph.D. | Nonlinear Interferometric Vibrational Imaging. efficient detection of Coherent Anti-Stokes Raman Scattering

Opt Photonics News
Nonlinear Interferometric Vibrational Imaging. efficient detection of Coherent Anti-Stokes Raman Scattering

McAlpine, C. S., Marks, D., Vinegoni, C., Bredfeldt, J., and Boppart^#, S.A.

Optics & Photonics News 2005

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For decades, Raman scattering has been a useful tool for probing the molecular contents of gases, liquids and biological media.1 Its strength is that it can identify molecules non-invasively based on their resonant vibrational frequencies. The technique uses optical frequency radiation, which is relatively easy to create, manipulate and detect. Unfortunately, the Raman effect is rather weak: Typically only one in a million photons is converted to the detected Raman radiation, so it is too slow to be used as a clinical diagnostic tool or to monitor fast biological processes. Using pulsed laser illumination, Coherent Anti-Stokes Raman Scattering (CARS) can stimulate the production of many more Raman photons by simultaneously exciting the molecular vibrations and detecting the emitted stimulated Raman scattering.
@article{2005-OPN, author= {McAlpine, C. S. and Marks, D. and Vinegoni, C. and Bredfeldt, J. and Boppart<sup>#</sup>, S.A.}, title= {Nonlinear Interferometric Vibrational Imaging. efficient detection of Coherent Anti-Stokes Raman Scattering}, journal= {Optics & Photonics News}, alternatejournal = {Opt Photonics News }, year = {2005}, volume = {16}, pages = {23}, doi = {10.1364/OPN.16.12.000023}, }
10.1364/OPN.16.12.000023

Abstract

"For decades, Raman scattering has been a useful tool for probing the molecular contents of gases, liquids and biological media.1 Its strength is that it can identify molecules non-invasively based on their resonant vibrational frequencies. The technique uses optical frequency radiation, which is relatively easy to create, manipulate and detect. Unfortunately, the Raman effect is rather weak: Typically only one in a million photons is converted to the detected Raman radiation, so it is too slow to be used as a clinical diagnostic tool or to monitor fast biological processes. Using pulsed laser illumination, Coherent Anti-Stokes Raman Scattering (CARS) can stimulate the production of many more Raman photons by simultaneously exciting the molecular vibrations and detecting the emitted stimulated Raman scattering."

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McAlpine, C. S., Marks, D., Vinegoni, C., Bredfeldt, J., & Boppart^#, S. A. (2005). Nonlinear Interferometric Vibrational Imaging. efficient detection of Coherent Anti-Stokes Raman Scattering. Optics & Photonics News, 16, 23. https://doi.org/10.1364/OPN.16.12.000023