Claudio Vinegoni, Ph.D. | Spectroscopic spectral-domain optical coherence microscopy

Opt. Lett.
Spectroscopic spectral-domain optical coherence microscopy

Xu, C. Y., Vinegoni, C., Ralston, T. S., Luo, W., Tan, W., and Boppart^#, S. A.

Optics Letters 2006

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The spectroscopic content within optical coherence tomography (OCT) data can provide a wealth of information. Spectroscopic OCT methods are frequently limited by time-frequency trade-offs that limit high spectral and spatial resolution simultaneously. We present spectroscopic spectral-domain optical coherence microscopy performed with a multimodality microscope. Restricting the spatial extent of the signal by using high-numerical-aperture optics makes high-resolution spectroscopic information accessible, facilitated with spectral-domain detection. Simultaneous acquisition of multiphoton microscopy images is used to validate tissue structure and localization of nuclei within individual cells. (c) 2006 Optical Society of America.
@article{2006-OL-1, author= {Xu, C. Y. and Vinegoni, C. and Ralston, T. S. and Luo, W. and Tan, W. and Boppart<sup>#</sup>, S. A.}, title= {Spectroscopic spectral-domain optical coherence microscopy}, journal= {Optics Letters}, alternatejournal = {Opt. Lett.}, year = {2006}, volume = {31}, number = {8}, pages = {1079-1081}, issn = {0146-9592}, doi = {10.1364/ol.31.001079}, pmid= {16625909} }
16625909

10.1364/ol.31.001079

Abstract

"The spectroscopic content within optical coherence tomography (OCT) data can provide a wealth of information. Spectroscopic OCT methods are frequently limited by time-frequency trade-offs that limit high spectral and spatial resolution simultaneously. We present spectroscopic spectral-domain optical coherence microscopy performed with a multimodality microscope. Restricting the spatial extent of the signal by using high-numerical-aperture optics makes high-resolution spectroscopic information accessible, facilitated with spectral-domain detection. Simultaneous acquisition of multiphoton microscopy images is used to validate tissue structure and localization of nuclei within individual cells. (c) 2006 Optical Society of America."

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Xu, C. Y., Vinegoni, C., Ralston, T. S., Luo, W., Tan, W., & Boppart^#, S. A. (2006). Spectroscopic spectral-domain optical coherence microscopy. Optics Letters, 31(8), 1079–1081. https://doi.org/10.1364/ol.31.001079