Claudio Vinegoni, Ph.D. | Two-photon imaging of pancreatic beta cells in real time in vivo

Technology
Two-photon imaging of pancreatic beta cells in real time in vivo

Clardy, S. M., Kohler, R., Vinegoni, C., Iwamoto, Y., Keliher, E., and Weissleder^#, R.

Technology 2016

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Here we present the first generation of two-photon beta cell specific in vivo imaging probes based on GLP1R targeting peptides. Among the three compounds of potential interest, we found quite unexpectedly that a squarine-rotaxane conjugate (2PEx-647) had near ideal in vivo imaging characteristics.
@article{2016-TECHNOL, author= {Clardy, S. M. and Kohler, R. and Vinegoni, C. and Iwamoto, Y. and Keliher, E. and Weissleder<sup>#</sup>, R.}, title= {Two-photon imaging of pancreatic beta cells in real time in vivo}, journal= {Technology}, alternatejournal = {Technology}, year = {2016}, volume = {4}, pages = {130-34}, doi = {10.1142/S2339547816200028}, }
10.1142/S2339547816200028

Abstract

"Here we present the first generation of two-photon beta cell specific in vivo imaging probes based on GLP1R targeting peptides. Among the three compounds of potential interest, we found quite unexpectedly that a squarine-rotaxane conjugate (2PEx-647) had near ideal in vivo imaging characteristics."

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For attribution in academic contexts, please cite this work as:

Clardy, S. M., Kohler, R., Vinegoni, C., Iwamoto, Y., Keliher, E., & Weissleder^#, R. (2016). Two-photon imaging of pancreatic beta cells in real time in vivo. Technology, 4, 130–134. https://doi.org/10.1142/S2339547816200028