Claudio Vinegoni, Ph.D. | Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration

Nat. Neurosci.
Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration

Herisson, F., Frodermann, V., Courties, G., Rohde, D., Sun, Y., Vandoorne, K., Wojtkiewicz, G. R., Masson, G. S., Vinegoni, C., Kim, J., Kim, D. E., Weissleder, R., Swirski, F. K., Moskowitz, M. A., and Nahrendorf^#, M.

Nature Neuroscience 2018

ABS URL PMID DOI PMCID CITE HTML PDF

Innate immune cells recruited to inflammatory sites have short life spans and originate from the marrow, which is distributed throughout the long and flat bones. While bone marrow production and release of leukocyte increases after stroke, it is currently unknown whether its activity rises homogeneously throughout the entire hematopoietic system. To address this question, we employed spectrally resolved in vivo cell labeling in the murine skull and tibia. We show that in murine models of stroke and aseptic meningitis, skull bone marrow-derived neutrophils are more likely to migrate to the adjacent brain tissue than cells that reside in the tibia. Confocal microscopy of the skull-dura interface revealed myeloid cell migration through microscopic vascular channels crossing the inner skull cortex. These observations point to a direct local interaction between the brain and the skull bone marrow through the meninges.
@article{2018-NATNEURO, author= {Herisson, F. and Frodermann, V. and Courties, G. and Rohde, D. and Sun, Y. and Vandoorne, K. and Wojtkiewicz, G. R. and Masson, G. S. and Vinegoni, C. and Kim, J. and Kim, D. E. and Weissleder, R. and Swirski, F. K. and Moskowitz, M. A. and Nahrendorf<sup>#</sup>, M.}, title= {Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration}, journal= {Nature Neuroscience}, alternatejournal = {Nat. Neurosci.}, year = {2018}, volume = {21}, number = {9}, pages = {1209-+}, issn = {1097-6256}, doi = {10.1038/s41593-018-0213-2}, pmcid = {PMC6148759 }, pmid= {30150661} }
30150661

PMC6148759

10.1038/s41593-018-0213-2

Abstract

"Innate immune cells recruited to inflammatory sites have short life spans and originate from the marrow, which is distributed throughout the long and flat bones. While bone marrow production and release of leukocyte increases after stroke, it is currently unknown whether its activity rises homogeneously throughout the entire hematopoietic system. To address this question, we employed spectrally resolved in vivo cell labeling in the murine skull and tibia. We show that in murine models of stroke and aseptic meningitis, skull bone marrow-derived neutrophils are more likely to migrate to the adjacent brain tissue than cells that reside in the tibia. Confocal microscopy of the skull-dura interface revealed myeloid cell migration through microscopic vascular channels crossing the inner skull cortex. These observations point to a direct local interaction between the brain and the skull bone marrow through the meninges."

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For attribution in academic contexts, please cite this work as:

Herisson, F., Frodermann, V., Courties, G., Rohde, D., Sun, Y., Vandoorne, K., Wojtkiewicz, G. R., Masson, G. S., Vinegoni, C., Kim, J., Kim, D. E., Weissleder, R., Swirski, F. K., Moskowitz, M. A., & Nahrendorf^#, M. (2018). Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration. Nature Neuroscience, 21(9), 1209-+. https://doi.org/10.1038/s41593-018-0213-2