Claudio Vinegoni, Ph.D.

Physicist

Asst. Professor
   CV |    Google Scholar
Center for Systems Biology, MGH - Harvard University .
Richard B. Simches Research Center, 185 Cambridge Street, Suite 5.210
Boston, MA 02114 (U.S.A.)

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Center for Systems Biology

MGH - Harvard University

Suite 5.210

185 Cambridge Street

Boston, MA 02114 (U.S.A.)

Hi! You’ve reached the Home Page of Dr. Claudio Vinegoni.
I am currently Assistant Professor of Radiology at the Center for Systems Biology @Harvard Medical School and Massachusetts General Hospital. To learn more about me, have a look at my Curriculum Vitae.

My current research activity focuses on analyzing, at a system level, how biological molecules, proteins and cells interact in both healthy and diseased states with particular emphasis in complex human conditions such as cancer, and cardiovascular diseases. Specifically, in my lab we develop innovative in vivo and ex vivo optical imaging modalities as well as software tools for fast acquisition, visualization and image analysis of large microscopy data sets at both the single cell- as well as the whole organ-level. For more details on my research, have a look at my publications and my current research projects.

Besides, I am interested in deep learning and machine learning.

I earned the Ph.D. and M.S. degrees in Physics from University of Geneva and Universita di Trento in 2002 and 1996, respectively.

  • My M.S. thesis focused on the design of optical methods and methodologies for Raman and Brillouin spectroscopy and lifetime imaging in solid state physics to characterize novel materials.
  • My doctoral research focused on the study of nonlinear optical effects in optical fibers at telecom wavelenghts and the design of novel metrology methods to determine critical parameters for increasing total bandwidth transmissions.

Selected publications–past and present–are included below. Feel free to browse my publications for my body of work.

Current research interests:

  • Motion compensation algorithm and hardware solution for optical imaging
  • Two photon imaging
  • In vivo drug imaging microscopy methods
  • High-content imaging and data analysis
  • Deep Learning methods applied in optical microscopy
  • Tomography optical imaging

Past research work:

  • Photoacoustic imaging
  • Telecom metrology
  • Optical Coherence Tomography and CARS imaging for label free imaging
  • Solid state phyisics

Select Publications [full list]

  1. Sci. Rep.
    Fluorescence microscopy tensor imaging representations for large-scale dataset analysis
    Vinegoni#†, C., Feruglio†, P. F., Courties, G., Schmidt, S., Hulsmans, M., Lee, S., Wang, R., Sosnovik, D., Nahrendorf, M., and Weissleder, R.
    Scientific Reports 2020
  2. Adv. Drug Deliv. Rev.
    Fluorescence anisotropy imaging in drug discovery
    Vinegoni#, C., Feruglio, P. F., Gryczynski, I., Mazitschek, R., and Weissleder, R.
    Advanced Drug Delivery Reviews 2019
  3. Nat. Chem. Biol.
    Quantitating drug-target engagement in single cells in vitro and in vivo
    Dubach, J. M., Kim, E., Yang, K., Cuccarese, M., Giedt, R. J., Meirnetis, L. G., Vinegoni#, C., and Weissleder#, R.
    Nature Chemical Biology 2017
  4. Nat. Protoc.
    Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging
    Vinegoni#, C., Fumene Feruglio, P., Brand, C., Lee, S., Nibbs, A. E., Stapleton, S., Shah, S., Gryczynski, I., Reiner, T., Mazitschek, R., and Weissleder, R.
    Nature Protocols 2017
  5. Nat. Commun.
    Real-time high dynamic range laser scanning microscopy
    Vinegoni#†, C., Swisher†, C. L., Fumene Feruglio†, P., Giedt, R. J., Rousso, D. L., Stapleton, S., and Weissleder, R.
    Nature Communications 2016
  6. Drug Discov. Today
    Advances in measuring single-cell pharmacology in vivo
    Vinegoni#, C., Dubach, J. M., Thurber, G. M., Miller, M. A., Mazitschek, R., and Weissleder, R.
    Drug Discovery Today 2015
  7. Nat. Protoc.
    Imaging the beating heart in the mouse using intravital microscopy techniques
    Vinegoni#†, C., Aguirre†, A. D., Lee, S., and Weissleder, R.
    Nature Protocols 2015
  8. P.N.A.S.
    Intravital imaging of cardiac function at the single-cell level
    Aguirre, A. D., Vinegoni#, C., Sebas, M., and Weissleder#, R.
    Proceedings of the National Academy of Sciences of the United States of America 2014
  9. Nat. Commun.
    In vivo imaging of specific drug-target binding at subcellular resolution
    Dubach†, J. M., Vinegoni#†, C., Mazitschek, R., Fumene Feruglio, P., Cameron, L. A., and Weissleder, R.
    Nature Communications 2014
  10. Nat. Commun.
    Real-time in vivo imaging of the beating mouse heart at microscopic resolution
    Lee†, S., Vinegoni#†, C., Fumene Feruglio, P., Fexon, L., Gorbatov, R., Pivoravov, M., Sbarbati, A., Nahrendorf, M., and Weissleder, R.
    Nature Communications 2012
  11. Sci. Transl. Med.
    Indocyanine Green Enables Near-Infrared Fluorescence Imaging of Lipid-Rich, Inflamed Atherosclerotic Plaques
    Vinegoni, C., Botnaru, I., Aikawa, E., Calfon, M. A., Iwamoto, Y., Folco, E. J., Ntziachristos, V., Weissleder, R., Libby, P., and Jaffer#, F. A.
    Science Translational Medicine 2011
  12. Nat. Photonics
    Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo
    Razansky#, D., Distel, M., Vinegoni, C., Ma, R., Perrimon, N., Koster, R. W., and Ntziachristos#, V.
    Nature Photonics 2009
  13. Nat. Methods
    In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography
    Vinegoni#†, C., Pitsouli†, C., Razansky†, D., Perrimon, N., and Ntziachristos, V.
    Nature Methods 2008

Select Proceedings [full list]

  1. 2020-BIBE
    Video-rate acquisition fluorescence microscopy via generative adversarial networks
    Issa, T.B., Vinegoni, C., Shaw, A., Feruglio, P.F., Weissleder, R., and Uminsky, D.
    In 2020 IEEE 20th International Conference on Bioinformatics and Bioengineering (BIBE) 2020


contact

Claudio Vinegoni, PhD
Assistant Professor
Center for Systems Biology
MGH - Harvard University
185 Cambridge Street
Boston, MA 02114 (U.S.A.)

cvinegoni 'at' mgh 'dot' harvard 'dot' edu